You can use other shaders for Spine rendering in Unity, but it requires that the shader you use has the following characteristics:
- no backface culling
 
- matches the premultiply alpha settings of your atlas export
 
If your shader writes to depth, you need to add z-spacing under the Advanced foldout to prevent z-fighting.
If your shader requires normals, check "Add Normals".
If your shader requires tangents, check "Solve Tangents"